Verkuijl, J. Feringa, Chirality , , 23 , 34— Boelo Schuur, Bastiaan J. Verkuijl, Adriaan J. Minnaard, Johannes G. Heeres and Ben L. Feringa, Org. Chiral separation by enantioselective liquid—liquid extraction.
Schuur, B. Bokhove, A. Minnaard, J. Heeres, B. Feringa Tetrahedron , , 67 , Sperotto, G. The mechanism of the modified Ullmann reaction. Orbegozo, J. Kroutil, Eur. Verkuijl, A. Schoonen, A. Feringa, Eur. Stegink, L. Lefort, A. Mutti, A. Orthaber, J. Schrittwieser, J. Pietschnig and W. Kroutil, Chem. Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents.
Szymanski, C. Postema, C. Tarabiono, F. Campbell-Verduyn, S. Feringa, D. Janssen, Adv. Lloyd-Jones, A. Robinson, L. Lefort, J. Rangheard, C. Phua, J. Hoorn, L. At the frontier between heterogeneous and homogeneous catalysis: hydrogenation of olefins and alkynes with soluble iron nanoparticles. Busscher, L. Cremers , M. Mottinelli, R. Wiertz, B. Okamura, Y. Yusa, K. Matsumura, H. Shimizu, J. Tetrahedron: Asymmetry , , 21 , — Efficient preparation of an N-aryl b -amino acid via asymmetric hydrogenation and direct asymmetric reductive amination en route to Ezetimibe.
Boogers, J. Jerphagnon, R. Haak, F. Berthiol, A. Gayet, V. Ritleng, A. Holuigue, N. Pannetier, M. Pfeffer, A. Voelklin, L. Lefort, G. Verzijl, C. Tarabiono, D. Janssen, A. Schuur, J. Winkelman, J. Heeres, Chem. Experimental and modeling studies on the enantio-separation of 3,5-dinitrobenzoyl- R , S -leucine by continuous liquid—liquid extraction in a cascade of centrifugal contactor separators.
Verkuijl, B. Schuur, A. Chiral separation of substituted phenylalanine analogues using chiral palladium phosphine complexes with enantioselective liquid—liquid extraction. C—N Coupling of nitrogen nucleophiles with aryl and heteroaryl bromides usingaminoarenethiolato—copper I pre- catalyst.
Boogers, T. Kuilman, R. Janssen, H. Straatman, J. Boogers, D. Sartor, U. Felfer, M. Kotthaus, G. Steinbauer, B. Dielemans, L. Challenges, Approaches and Solutions , 2 nd ed. Blaser, H. Federsel, Eds. Asymmetric Hydrogenation of a 2-isopropylcinnamic acid derivative en route to the blood pressure lowering agent Aliskiren. Jerphagnon, A. Asymmetric hydrogenation of 2-substituted N-protected-indoles catalyzed by rhodium complexes of BINOL-derived phosphoramidites.
Verkuijl, W. Wu, A. Minnaard, D. Janssen, J. Feringa, Chem. Slagt, A. Kellogg, Org. Schuur, M. Steensma, J. Heeres, Chimica Oggi , , 27 6 , Supplement on chiral technologies p Continuous enantioseparation by liquid-liquid extraction. Gayet, F. Berthiol, V. Ritleng, N. Meetsma, M. Feringa and J.
Catal , , , Asymmetric Hydrogenation of Quinoxalines Catalyzed. Swennenhuis, R. Chen, P. Hallett, J. Heeres, Org. Orbegozo, I. Lavandera, W. Fabian, B. Mautner, J. Kroutil, Tetrahedron , , 65 , Biocatalytic oxidation of benzyl alcohol to benzaldehyde via hydrogen transfer.
Phua, L. Boogers, M. Tristany and J. Soluble iron nanoparticles as cheap and environmentally benign alkene and alkyne hydrogenation catalysts. Ager, L. Soloshonok, K. Izawa, eds. Catalyst screening for the synthesis of amino acids.
Hallett, G. Kwant, J. Kraai, B. Schuur, F. Haak, A. Feringa, H. Heeres and J. Prunier, Ed. Process intensification. Berthiol, T. Gayet, C. Tarabiono, C. Postema, V. Ritleng, M. Pfeffer, D. Ager and J. From monodentate to bidentate to monodentate with a trillion possibilities. Floure, A. Kraai, J. Heeres, Biochem. Kinetic studies on the Rhizomucor miehei lipase catalyzed esterification reaction of oleic acid with 1-butanol in a biphasic system.
Swennenhuis, P. Kamer, Angew. Boogers, A. Ager, R. Jagt, A. Kraai, F. Schuur, H. Parallel Synthesis of Chiral P-Ligands. Kamer, Org. Solid-phase parallel synthesis of phosphite ligands.
Ager, O. May, J. In search of catalysts: making the trillion to one bet pay off. Djakovitch, K. Astruc, ed.
The role of palladium nanoparticles as catalysts for carbon-carbon coupling reactions. Hekking, L. Schoemaker, J. Rutjes, Adv. Meindertsma, M. Pollard, B. Minnaard, Tetrahedron:Asymmetry , , 18 , Feringa, L. Asymmetric Hydrogenation using Monodentate Phosphoramidite Ligands. Sperotto, J. Ligand-free copper I catalyzed N- and O-arylation of aryl halides.
MonoPhos Ligands: More than asymmetric hydrogenation. A little of this and none of that. Jagt, P. Toullec, E. Schudde, J. Feringa and A. Synthesis of solution-phase phosphoramidite and phosphite ligand libraries and their in situ screening in the rhodium-catalyzed asymmetric addition of arylboronic acids.
Huat Phua, S. Mathew, A. White, J. Blackmond and K. Hii , Chem. Elucidating the mechanism of the asymmetric aza-Michael reaction. Imbos, J. Boiteau, A. Duursma, J. De Vries, D. Boogers, U. Kotthaus, L. Steinbauer, A. A mixed ligand approach enables the asymmetric hydrogenation of an alpha-isopropyl-cinnamic acid en route to the renin-inhibitor Aliskiren.
Myers, J. Aggarwal , Angew,. Reactions of iminium ions with Michael acceptors through a Morita-Baylis-Hillman-type reaction: Enantiocontrol and applications in synthesis. Giacomina, A. Meetsma, L. Panella, L. Haak, C. Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution. Hoen, T. Tiemersma-Wegman, B.
Procuranti, L. Minnaard and B. Heller, A. Elsevier, eds. Catalyst Inhibition and Deactivation in Homogeneous Hydrogenation. High-throughput Experimentation and Ligand Libraries. High throughput screening of Monophos instant ligand library leads to a ton-scale asymmetric hydrogenation process. Baber, J. Orpen, P. Pringle, K. Dalton Trans. Allosteric effects in asymmetric hydrogenation catalysis? Asymmetric induction as a function of the substrate and the backbone flexibility of C-1 symmetric diphosphines in rhodium-catalysed hydrogenations.
Martina, R. Jagt, J. Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethylketones. Lambers-Verstappen, L. Schmieder-van de Vondervoort, N. Sereinig, R. Toullec, R. Feringa, A. Minnaard, Org. Wisman, J. Deelman and H. Kinetic studies on the asymmetric transfer hydrogenation of acetophenone using a homogeneous ruthenium catalyst with a chiral amino-alcohol ligand. M de Vries and J. Toullec, D. Geerdink, J. Minnaard, Angew. Sortais, L.
Pfeffer, Pure Appl. Cycloruthenated compounds as efficient catalyst for asymmetric hydride transfer reaction. Reeve, J. Cros, C. Gennari, U. Piarulli, and J. Toullec, J. Aleixandre, G. Kruidhof, J. Robertus, B. Phua, A. Hii, Adv. Jiang, L. Lefort, P. Goudriaan, A. Reek, Angew. A unifying mechanism for all high-temperature Heck reactions. The role of palladium colloids and anionic species. Ager, Ed. Jerphagnon, G. Christoffers and A. Baro, eds. KGaA, Weinheim, , p Important pharmaceuticals and intermediates, J.
Challenges and Solutions for Organic Synthesis. Catal, , , Effect of the chelating moiety. Locally Owned and Operated At J. Made from Scratch Menu Real food, freshly prepared with healthy and satisfying portions.
Gift Cards. Limited Time Specials Check out our seasonal rotating menu specials. Local Community Charities J. Read More. Visit Us. Drop Us a Line Don't be shy. Contact Us. See Our Menu. We were also pleased to find that the ECED process can also be performed directly on the acetal precursors, precluding the extra step to reveal the aldehyde motif, and without compromising the yield and enantiomeric excess of the reaction see 4f.
The ECED transformations shown in Table 2 display the electrophile and nucleophile in separate anisidine side chains, leading to a two directional closure to the tricyclic structure. Furthermore, each of these processes occur in excellent yields, do not affect the structural framework of the molecule and would be compatible with library synthesis. While our complexity generating transformation provides numerous opportunities to exploit the potential of post-ECED orthogonal functionalisation, we are restricted by the nature of the alkyne substituent that we need to install as part of our starting materials.
To address this limitation, we speculated that a bromo-substituted alkyne motif may also be compatible with the ECED process and would accordingly result in a versatile handle for further functionalisation.
0コメント